導(dǎo)師簡(jiǎn)介

姓名：徐鈞   性別：男   政治面貌：中共黨員

學(xué)歷：研究生 學(xué)位：博士   職稱：主任醫(yī)師        

博、碩導(dǎo)師：博士生導(dǎo)師   本崗位工作年數(shù)：33年

研究方向：肝移植的臨床及基礎(chǔ)研究

榮譽(yù)稱號(hào)：享受?chē)?guó)務(wù)院特殊津貼專家，山西名醫(yī)，山西省學(xué)術(shù)技術(shù)帶頭人，三晉英才高端領(lǐng)軍人才，省委聯(lián)系高級(jí)專家。

學(xué)術(shù)任職：中華醫(yī)學(xué)會(huì)外科分會(huì)微創(chuàng)外科學(xué)組委員，中華醫(yī)學(xué)會(huì)器官移植學(xué)分會(huì)委員，中國(guó)醫(yī)師協(xié)會(huì)外科分會(huì)常務(wù)委員，中國(guó)醫(yī)師協(xié)會(huì)器官移植醫(yī)師分會(huì)委員，山西省抗癌協(xié)會(huì)理事長(zhǎng)，山西省醫(yī)學(xué)會(huì)常務(wù)理事，山西省醫(yī)學(xué)會(huì)微創(chuàng)外科專業(yè)委員會(huì)主任委員，山西省醫(yī)學(xué)會(huì)普外科專業(yè)委員會(huì)主任委員，山西省醫(yī)學(xué)會(huì)器官移植專業(yè)委員會(huì)副主任委員，山西省醫(yī)師協(xié)會(huì)內(nèi)鏡醫(yī)師分會(huì)普外科學(xué)組主任委員。

近五年承擔(dān)科研課題情況：

1、消化系疾病及器官移植山西省重點(diǎn)實(shí)驗(yàn)室，山西省科技廳，202204010931008，300萬(wàn)元，2023.1-2024.12

2、國(guó)家自然科學(xué)基金面上項(xiàng)目，82072737，circRNA0007766/miR4492/MET/PI3K-Akt通路調(diào)控食管胃結(jié)合部腺癌增殖和侵襲的分子機(jī)制研究，2021/01-2024/12，55萬(wàn)元，主持。

3、山西省科學(xué)技術(shù)廳，中央引導(dǎo)地方專項(xiàng)，YDZJSX2021B012，肝移植術(shù)后免疫排斥反應(yīng)評(píng)估研究科技創(chuàng)新基地，2021/08-2023/12，90萬(wàn)元，在研。

4、山西省衛(wèi)生健康委，2020085，子宮內(nèi)膜間充質(zhì)干細(xì)胞通過(guò)gp130-Src-YAP通路調(diào)控肝移植術(shù)后免疫排斥反應(yīng)的機(jī)制研究，2021/01-2022/12,3萬(wàn)元，主持。

5、山西省衛(wèi)生健康委員會(huì)，創(chuàng)新團(tuán)隊(duì)，2020TD08，肝臟移植研究科技領(lǐng)軍團(tuán)隊(duì)，2021-01至2023-12，20萬(wàn)元，在研，主持。

代表性論著及近五年的代表性論文（限10項(xiàng)以內(nèi)）：

1. Jia Yao，Tian Liu，Qiang ZhaoYaqiu Ji，Jinjia Bai，Han Wang，Ruoyu Yao，Xiaoshuang Zhou，Yu Chen，Jun Xu. Genetic landscape and immune mechanism of monocytes associated with the progression of acuteonchronic liver failure. Hepatology Internationa.2023 Jun;17(3)

2. Zihe Zhu, Qianqian Zhang, Lixin Liu, Jun Xu. Human umbilical cord  Mesenchymal stem cell's cultivation of treatment liver diseases. Curr Stem cell Res Ther. 2022. Jun 23(IF=3.758)

3. Lai Z, Chen Z, Zhang A, Huo C and Xu J (2022) The Gut Microbiota in Liver Transplantation Recipients During the Perioperative Period. Front. Physiol. 2022;13(IF=4.755)

4. Gaopeng Li, Guoliang Wang, Fenqing Chi, Yuqi Jia, Xi Wang, Quankai Mu, Keru Qin, Xiaoxia Zhu, Jing Pang, Baixue Xu, Guangen Feng, Yuhu Niu, Tao Gong, Hongwei Zhang, Xiushan Dong, Ting Liu, Jinfeng Ma, Zefeng Gao, Kai Tao, Feng Li, Jun Xu*, Baofeng Yu*. Higher postoperative plasma EV PD- L1 predicts poor survival in patients with gastric cancer. Journal for Immuno Therapy of Cancer . doi:10.1136/ jitc-2020-002218.

5. Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu*, Jun Xu* and Jun Xie*. Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics Chromatin. 2021 Dec 4;14(1):52.

6. Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang and Jun Xu. KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway. Cell Biosci (2021) 11:73.

7. Yarong Guo, Jun Xu, Qiang Du, Yihe Yan, David A. Geller. IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin.Transl Oncol 2021 Jun;14(6).

8. Jia Yao, Zhou X, Yuan L, Niu LY, Zhang A, Shi H, Duan Z, Xu J*. Prognostic value of the third lumbar skeletal muscle mass index in patients with liver cirrhosis and ascites. Clin Nutr. 2020 Jun;39(6):1908-1913.

9. Li Zhang, Juan Zhang, Dandan Li, Ping Yan, Ajab Khan, Xueqin Liu, Lei Wang, Zhizhen Liu, Jianbing Mu, Jun Xu, Bo Niu*, Jun Xie*. Excessive apoptosis and ROS induced by ethionine affects neural cells viability and differentiation[J]. Acta Biochimica et Biophysica Sinica 2020, Oct, 10;gmaa093.

10. Meng T, Fan B, Li Q, Peng X, Xu J, Zhang R. Matrix metalloproteinase-initiated aggregation of melanin nanoparticles as highly efficient contrast agent for enhanced tumor accumulation and dual-modal imaging.J Mater Chem B 2020 Oct 09.